Xerostomia Treatment Guidelines: How Dry Mouth feels - a desert landscape
Xerostomia Treatment Guidelines: How Dry Mouth feels - a desert landscape
Xerostomia Treatment Guidelines: How Dry Mouth feels - a desert landscape

Xerostomia Treatment Guidelines

Xerostomia Treatment Guidelines

Written by

Nickolas Steel

Published

Jul 25, 2025

Xerostomia (ZEER-oh-STOH-mee-ah), commonly known as dry mouth, is a frequent condition in dental practice. It occurs when the salivary glands produce less saliva, leading to dryness and discomfort in the mouth.

Although it may seem minor, xerostomia can significantly impact oral health and long-term dental outcomes. Understanding its causes, symptoms, and treatments is vital for providing optimal patient care.

Symptoms and Consequences

Saliva is essential for oral health. It lubricates the mouth, neutralizes harmful acids, and removes food particles and bacteria. Without sufficient saliva, patients may experience:

Xerostomia can also affect overall quality of life, causing sleep disturbances, eating challenges, and social anxiety due to bad breath or speaking difficulties.

Xerostomia Causes and Risk Factors

Aging

Aging naturally reduces salivary gland efficiency, which can lead to dry mouth. Older adults are also more likely to take medications that exacerbate this condition.

Medications

Many prescription and over-the-counter medications can cause xerostomia as a side effect. These include:

  • Antidepressants

  • Antihistamines

  • Blood pressure medications

  • Diabetes medications (e.g., metformin)

  • Opioid pain medications

  • Inhalers for asthma and COPD (propylene glycol-related xerostomia)

*We detail all of these in our dental medication database (DMD) available through DentalRx Instant Search!

Radiation Therapy

Radiation for head and neck cancer can damage salivary glands, significantly reducing saliva production. This effect may be temporary or permanent depending on the treatment dose.

Autoimmune Disorders

Conditions like Sjögren’s syndrome directly affect salivary glands, leading to chronic dry mouth. Other autoimmune diseases may contribute indirectly through medication use or systemic inflammation.

CPAP and Dry Mouth

Patients using Continuous Positive Airway Pressure (CPAP) therapy for sleep apnea often experience dry mouth. The airflow can dry oral tissues, especially if the patient breathes through their mouth during sleep. Mitigation strategies include:

  • Using a CPAP humidifier

  • Staying hydrated

  • Saliva substitutes or moisturizing products

Dehydration

Dehydration, whether from illness, inadequate fluid intake, or excessive fluid loss, reduces saliva production. Maintaining proper hydration is essential for managing xerostomia.

Smoking and Nicotine Use

Smoking reduces saliva production and irritates oral tissues, exacerbating dryness and increasing the risk of gum disease and oral cancer. The local effects of nicotine pouches can also decrease saliva production.

HIV and AIDS

Dry mouth is common in HIV-positive individuals, caused either by the virus’s direct effects on salivary glands or side effects of antiretroviral therapy (ART). This can lead to higher risks of tooth decay, oral candidiasis, and gum disease.

Hormonal Changes: Pregnancy and Menopause

Pregnancy: Hormonal changes, increased metabolic demands, and dehydration can lead to xerostomia. Common triggers include gestational diabetes, morning sickness, and medication use. Encouraging hydration and using saliva substitutes can help.

Menopause: Declining estrogen levels during menopause reduce saliva production, increasing the risk of tooth decay, gum disease, and oral infections. Good oral hygiene and hydration can alleviate symptoms.

COVID-19 and Xerostomia

COVID-19 may directly affect salivary glands, reducing saliva production. Dehydration from fever or illness, along with medications like antivirals and steroids, can exacerbate dry mouth. Managing these symptoms is crucial to prevent oral complications.

Diagnosis

A dental professional can diagnose xerostomia through medical and dental history, physical examination, and a salivary flow test. Saliva flow rates are classified as:

  • Mild: Above 0.2 ml/min

  • Moderate: 0.1–0.2 ml/min

  • Severe: Below 0.1 ml/min

Xerostomia Treatment and Management

First-line treatment options for dry mouth:

  • Over-the-counter, sugar-free lozenges, mints, gums

    • Chew 1-2 pieces four times per day after meals as needed for dry mouth

  • Saliva substitutes

    • Use four times per day after meals as needed for dry mouth

  • Oral rinses like saline water or alkaline water (1/4 tsp baking soda + water)

    • Swish and spit four times per day after meals as needed for dry mouth

  • Management of underlying medical conditions

    • Work with the patients family physician to facilitate management

  • Lifestyle changes (e.g., quitting smoking or other nicotine products, proper hydration, etc)

  • Regular dental check-ups at least twice per year are recommended to prevent decay and gum disease.

Common over-the-counter products:

  • ACT Dry Mouth Lozenges, alcohol-free mouthwash, and sugar-free gum

  • XyliMelts Mints

  • Saliva substitutes like Biotene Moisturizing Spray

    • Note: saliva substitutes are not the most pleasant due to taste and texture

Fluoride Treatment in Patients with Xerostomia:

Additional consideration should be made into fluoride treatments to prevent carries and decay in prolonged cases of dry mouth. Fluoride treatments include:

  • Fluoride 0.5% varnish at hygiene appointments

  • 1.1% sodium fluoride gel (PreviDent) applied daily

  • Fluoride containing toothpaste brushed twice per day

Second-line treatment options for dry mouth:

Prescription medications to stimulate saliva production are sometimes required if first-line options don't work. These prescriptions include:

  • Pilocarpine

  • Cevimeline

  • Magic Mouthwash or Pink Lady oral rinse

    • Consider referral to an otolaryngologist (ENT) if necessary for these prescriptions

Prevention of Xerostomia

Preventing xerostomia involves addressing underlying causes and making lifestyle changes. Effective strategies include:

  • Stay Hydrated: Drink plenty of water throughout the day to maintain proper hydration.

  • Limit Caffeine and Alcohol: Reduce consumption of these substances as they can contribute to dehydration.

  • Use a Humidifier: Adding moisture to the air, especially at night, can help alleviate dryness.

  • Avoid Nicotine Products: Quit smoking or using nicotine to prevent further reduction in saliva production.

  • Maintain Good Oral Hygiene: Brush and floss regularly to minimize the risk of tooth decay and gum disease.

  • Choose Saliva-Friendly Foods: Opt for moist, soft foods and avoid dry or salty items that can worsen symptoms.

  • Review Medications: Work with a healthcare provider to adjust medications that may be contributing to dry mouth.

  • Schedule Regular Dental Checkups: Scheduling your patient for regular dental check-ups can help identify early signs of xerostomia and related complications.

Additional Resources

For more information:

Dental Guidelines at your Fingertips with DentalRx

DentalRx provides this guideline and many more dental pharmacology resources in an accessible web and mobile app. Start using the App today!

Conclusion

Xerostomia is a common but significant condition affecting oral health and quality of life. By understanding its causes, symptoms, and treatments, dental professionals can provide comprehensive care and collaborate with other healthcare providers to improve patient outcomes.

References

Xerostomia (ZEER-oh-STOH-mee-ah), commonly known as dry mouth, is a frequent condition in dental practice. It occurs when the salivary glands produce less saliva, leading to dryness and discomfort in the mouth.

Although it may seem minor, xerostomia can significantly impact oral health and long-term dental outcomes. Understanding its causes, symptoms, and treatments is vital for providing optimal patient care.

Symptoms and Consequences

Saliva is essential for oral health. It lubricates the mouth, neutralizes harmful acids, and removes food particles and bacteria. Without sufficient saliva, patients may experience:

Xerostomia can also affect overall quality of life, causing sleep disturbances, eating challenges, and social anxiety due to bad breath or speaking difficulties.

Xerostomia Causes and Risk Factors

Aging

Aging naturally reduces salivary gland efficiency, which can lead to dry mouth. Older adults are also more likely to take medications that exacerbate this condition.

Medications

Many prescription and over-the-counter medications can cause xerostomia as a side effect. These include:

  • Antidepressants

  • Antihistamines

  • Blood pressure medications

  • Diabetes medications (e.g., metformin)

  • Opioid pain medications

  • Inhalers for asthma and COPD (propylene glycol-related xerostomia)

*We detail all of these in our dental medication database (DMD) available through DentalRx Instant Search!

Radiation Therapy

Radiation for head and neck cancer can damage salivary glands, significantly reducing saliva production. This effect may be temporary or permanent depending on the treatment dose.

Autoimmune Disorders

Conditions like Sjögren’s syndrome directly affect salivary glands, leading to chronic dry mouth. Other autoimmune diseases may contribute indirectly through medication use or systemic inflammation.

CPAP and Dry Mouth

Patients using Continuous Positive Airway Pressure (CPAP) therapy for sleep apnea often experience dry mouth. The airflow can dry oral tissues, especially if the patient breathes through their mouth during sleep. Mitigation strategies include:

  • Using a CPAP humidifier

  • Staying hydrated

  • Saliva substitutes or moisturizing products

Dehydration

Dehydration, whether from illness, inadequate fluid intake, or excessive fluid loss, reduces saliva production. Maintaining proper hydration is essential for managing xerostomia.

Smoking and Nicotine Use

Smoking reduces saliva production and irritates oral tissues, exacerbating dryness and increasing the risk of gum disease and oral cancer. The local effects of nicotine pouches can also decrease saliva production.

HIV and AIDS

Dry mouth is common in HIV-positive individuals, caused either by the virus’s direct effects on salivary glands or side effects of antiretroviral therapy (ART). This can lead to higher risks of tooth decay, oral candidiasis, and gum disease.

Hormonal Changes: Pregnancy and Menopause

Pregnancy: Hormonal changes, increased metabolic demands, and dehydration can lead to xerostomia. Common triggers include gestational diabetes, morning sickness, and medication use. Encouraging hydration and using saliva substitutes can help.

Menopause: Declining estrogen levels during menopause reduce saliva production, increasing the risk of tooth decay, gum disease, and oral infections. Good oral hygiene and hydration can alleviate symptoms.

COVID-19 and Xerostomia

COVID-19 may directly affect salivary glands, reducing saliva production. Dehydration from fever or illness, along with medications like antivirals and steroids, can exacerbate dry mouth. Managing these symptoms is crucial to prevent oral complications.

Diagnosis

A dental professional can diagnose xerostomia through medical and dental history, physical examination, and a salivary flow test. Saliva flow rates are classified as:

  • Mild: Above 0.2 ml/min

  • Moderate: 0.1–0.2 ml/min

  • Severe: Below 0.1 ml/min

Xerostomia Treatment and Management

First-line treatment options for dry mouth:

  • Over-the-counter, sugar-free lozenges, mints, gums

    • Chew 1-2 pieces four times per day after meals as needed for dry mouth

  • Saliva substitutes

    • Use four times per day after meals as needed for dry mouth

  • Oral rinses like saline water or alkaline water (1/4 tsp baking soda + water)

    • Swish and spit four times per day after meals as needed for dry mouth

  • Management of underlying medical conditions

    • Work with the patients family physician to facilitate management

  • Lifestyle changes (e.g., quitting smoking or other nicotine products, proper hydration, etc)

  • Regular dental check-ups at least twice per year are recommended to prevent decay and gum disease.

Common over-the-counter products:

  • ACT Dry Mouth Lozenges, alcohol-free mouthwash, and sugar-free gum

  • XyliMelts Mints

  • Saliva substitutes like Biotene Moisturizing Spray

    • Note: saliva substitutes are not the most pleasant due to taste and texture

Fluoride Treatment in Patients with Xerostomia:

Additional consideration should be made into fluoride treatments to prevent carries and decay in prolonged cases of dry mouth. Fluoride treatments include:

  • Fluoride 0.5% varnish at hygiene appointments

  • 1.1% sodium fluoride gel (PreviDent) applied daily

  • Fluoride containing toothpaste brushed twice per day

Second-line treatment options for dry mouth:

Prescription medications to stimulate saliva production are sometimes required if first-line options don't work. These prescriptions include:

  • Pilocarpine

  • Cevimeline

  • Magic Mouthwash or Pink Lady oral rinse

    • Consider referral to an otolaryngologist (ENT) if necessary for these prescriptions

Prevention of Xerostomia

Preventing xerostomia involves addressing underlying causes and making lifestyle changes. Effective strategies include:

  • Stay Hydrated: Drink plenty of water throughout the day to maintain proper hydration.

  • Limit Caffeine and Alcohol: Reduce consumption of these substances as they can contribute to dehydration.

  • Use a Humidifier: Adding moisture to the air, especially at night, can help alleviate dryness.

  • Avoid Nicotine Products: Quit smoking or using nicotine to prevent further reduction in saliva production.

  • Maintain Good Oral Hygiene: Brush and floss regularly to minimize the risk of tooth decay and gum disease.

  • Choose Saliva-Friendly Foods: Opt for moist, soft foods and avoid dry or salty items that can worsen symptoms.

  • Review Medications: Work with a healthcare provider to adjust medications that may be contributing to dry mouth.

  • Schedule Regular Dental Checkups: Scheduling your patient for regular dental check-ups can help identify early signs of xerostomia and related complications.

Additional Resources

For more information:

Dental Guidelines at your Fingertips with DentalRx

DentalRx provides this guideline and many more dental pharmacology resources in an accessible web and mobile app. Start using the App today!

Conclusion

Xerostomia is a common but significant condition affecting oral health and quality of life. By understanding its causes, symptoms, and treatments, dental professionals can provide comprehensive care and collaborate with other healthcare providers to improve patient outcomes.

References

Xerostomia (ZEER-oh-STOH-mee-ah), commonly known as dry mouth, is a frequent condition in dental practice. It occurs when the salivary glands produce less saliva, leading to dryness and discomfort in the mouth.

Although it may seem minor, xerostomia can significantly impact oral health and long-term dental outcomes. Understanding its causes, symptoms, and treatments is vital for providing optimal patient care.

Symptoms and Consequences

Saliva is essential for oral health. It lubricates the mouth, neutralizes harmful acids, and removes food particles and bacteria. Without sufficient saliva, patients may experience:

Xerostomia can also affect overall quality of life, causing sleep disturbances, eating challenges, and social anxiety due to bad breath or speaking difficulties.

Xerostomia Causes and Risk Factors

Aging

Aging naturally reduces salivary gland efficiency, which can lead to dry mouth. Older adults are also more likely to take medications that exacerbate this condition.

Medications

Many prescription and over-the-counter medications can cause xerostomia as a side effect. These include:

  • Antidepressants

  • Antihistamines

  • Blood pressure medications

  • Diabetes medications (e.g., metformin)

  • Opioid pain medications

  • Inhalers for asthma and COPD (propylene glycol-related xerostomia)

*We detail all of these in our dental medication database (DMD) available through DentalRx Instant Search!

Radiation Therapy

Radiation for head and neck cancer can damage salivary glands, significantly reducing saliva production. This effect may be temporary or permanent depending on the treatment dose.

Autoimmune Disorders

Conditions like Sjögren’s syndrome directly affect salivary glands, leading to chronic dry mouth. Other autoimmune diseases may contribute indirectly through medication use or systemic inflammation.

CPAP and Dry Mouth

Patients using Continuous Positive Airway Pressure (CPAP) therapy for sleep apnea often experience dry mouth. The airflow can dry oral tissues, especially if the patient breathes through their mouth during sleep. Mitigation strategies include:

  • Using a CPAP humidifier

  • Staying hydrated

  • Saliva substitutes or moisturizing products

Dehydration

Dehydration, whether from illness, inadequate fluid intake, or excessive fluid loss, reduces saliva production. Maintaining proper hydration is essential for managing xerostomia.

Smoking and Nicotine Use

Smoking reduces saliva production and irritates oral tissues, exacerbating dryness and increasing the risk of gum disease and oral cancer. The local effects of nicotine pouches can also decrease saliva production.

HIV and AIDS

Dry mouth is common in HIV-positive individuals, caused either by the virus’s direct effects on salivary glands or side effects of antiretroviral therapy (ART). This can lead to higher risks of tooth decay, oral candidiasis, and gum disease.

Hormonal Changes: Pregnancy and Menopause

Pregnancy: Hormonal changes, increased metabolic demands, and dehydration can lead to xerostomia. Common triggers include gestational diabetes, morning sickness, and medication use. Encouraging hydration and using saliva substitutes can help.

Menopause: Declining estrogen levels during menopause reduce saliva production, increasing the risk of tooth decay, gum disease, and oral infections. Good oral hygiene and hydration can alleviate symptoms.

COVID-19 and Xerostomia

COVID-19 may directly affect salivary glands, reducing saliva production. Dehydration from fever or illness, along with medications like antivirals and steroids, can exacerbate dry mouth. Managing these symptoms is crucial to prevent oral complications.

Diagnosis

A dental professional can diagnose xerostomia through medical and dental history, physical examination, and a salivary flow test. Saliva flow rates are classified as:

  • Mild: Above 0.2 ml/min

  • Moderate: 0.1–0.2 ml/min

  • Severe: Below 0.1 ml/min

Xerostomia Treatment and Management

First-line treatment options for dry mouth:

  • Over-the-counter, sugar-free lozenges, mints, gums

    • Chew 1-2 pieces four times per day after meals as needed for dry mouth

  • Saliva substitutes

    • Use four times per day after meals as needed for dry mouth

  • Oral rinses like saline water or alkaline water (1/4 tsp baking soda + water)

    • Swish and spit four times per day after meals as needed for dry mouth

  • Management of underlying medical conditions

    • Work with the patients family physician to facilitate management

  • Lifestyle changes (e.g., quitting smoking or other nicotine products, proper hydration, etc)

  • Regular dental check-ups at least twice per year are recommended to prevent decay and gum disease.

Common over-the-counter products:

  • ACT Dry Mouth Lozenges, alcohol-free mouthwash, and sugar-free gum

  • XyliMelts Mints

  • Saliva substitutes like Biotene Moisturizing Spray

    • Note: saliva substitutes are not the most pleasant due to taste and texture

Fluoride Treatment in Patients with Xerostomia:

Additional consideration should be made into fluoride treatments to prevent carries and decay in prolonged cases of dry mouth. Fluoride treatments include:

  • Fluoride 0.5% varnish at hygiene appointments

  • 1.1% sodium fluoride gel (PreviDent) applied daily

  • Fluoride containing toothpaste brushed twice per day

Second-line treatment options for dry mouth:

Prescription medications to stimulate saliva production are sometimes required if first-line options don't work. These prescriptions include:

  • Pilocarpine

  • Cevimeline

  • Magic Mouthwash or Pink Lady oral rinse

    • Consider referral to an otolaryngologist (ENT) if necessary for these prescriptions

Prevention of Xerostomia

Preventing xerostomia involves addressing underlying causes and making lifestyle changes. Effective strategies include:

  • Stay Hydrated: Drink plenty of water throughout the day to maintain proper hydration.

  • Limit Caffeine and Alcohol: Reduce consumption of these substances as they can contribute to dehydration.

  • Use a Humidifier: Adding moisture to the air, especially at night, can help alleviate dryness.

  • Avoid Nicotine Products: Quit smoking or using nicotine to prevent further reduction in saliva production.

  • Maintain Good Oral Hygiene: Brush and floss regularly to minimize the risk of tooth decay and gum disease.

  • Choose Saliva-Friendly Foods: Opt for moist, soft foods and avoid dry or salty items that can worsen symptoms.

  • Review Medications: Work with a healthcare provider to adjust medications that may be contributing to dry mouth.

  • Schedule Regular Dental Checkups: Scheduling your patient for regular dental check-ups can help identify early signs of xerostomia and related complications.

Additional Resources

For more information:

Dental Guidelines at your Fingertips with DentalRx

DentalRx provides this guideline and many more dental pharmacology resources in an accessible web and mobile app. Start using the App today!

Conclusion

Xerostomia is a common but significant condition affecting oral health and quality of life. By understanding its causes, symptoms, and treatments, dental professionals can provide comprehensive care and collaborate with other healthcare providers to improve patient outcomes.

References

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to DentalRx — no strings attached.

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